lnplblnq

Candidate Sepsis Drug Could Prevent Flu Deaths

first_imgThe 1918 Spanish flu killed up to 40 million people. The swine flu pandemic in 2009 killed an estimated 284,000. Now, scientists have discovered a substance that could help doctors save lives during future influenza pandemics. Eritoran, a compound under investigation as a sepsis drug, dramatically reduces deaths from influenza in mice. “This could potentially open up a whole new class of anti-influenza drugs,” says Michael Osterholm, a flu expert at the Center for Infectious Disease Research and Policy at the University of Minnesota, Twin Cities, who was not involved in the work. At the moment, doctors have only one class of compounds available to combat influenza. The drugs, Tamiflu and Relenza, block neuraminidase, a surface protein that influenza viruses need to leave the cell after reproduction. The drugs, taken orally, have to be given soon after infection to be effective, however, and some flu strains have developed resistance against them. A few scientists have also questioned the safety and efficacy of the compounds, which many countries stockpiled during the 2009 H1N1 pandemic. “Basically, if you see the armamentarium we have today, it is limited and could be blown away overnight,” says Albert Osterhaus, a virologist at Erasmus MC in Rotterdam, the Netherlands. Instead of targeting the virus, immunologist Stefanie Vogel at the University of Maryland, Baltimore, tried to interfere with the host immune system. Scientists have long speculated that some severe influenza cases are not the direct result of the virus wreaking havoc, but due to a so-called cytokine storm, a catastrophic overactivation of the immune system that leads to numerous inflammatory substances being released in the whole body, which can result in multiple organ failure. For instance, immune cells and fluid can accumulate in the lungs, blocking the airways. In 2008, a study in Cell suggested that the cascade was triggered by the activation of a molecule called Toll-like receptor 4 (TLR4), which normally alerts the immune system to the presence of certain bacteria in the body. If these pathogens overwhelm the body, TLR4 is thought to also trigger the whole-body inflammation known as sepsis. For that reason, blocking TLR4 has been looked at as a potential treatment in patients suffering from sepsis. Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*) Vogel and her colleagues investigated eritoran, a compound that blocks TLR4 and is now in clinical trials as a sepsis drug. They infected mice with a lab strain of influenza called PR8 and gave half of them eritoran injections for 5 days, starting 2 days after infection. Ninety percent of untreated mice died, compared with only 10% of those given the drug. If treatment was started 6 days after infection, 33% of the animals survived. The compound also reduced lung damage in cotton rats, a species that does not die from the influenza strain used for the study, the authors report online today in Nature. “It’s an elegant study based on a rather bold hypothesis,” Osterhaus says. But the disease mechanism in mice could be different from that in humans, he says. “That does not disqualify the results, but it means we have to be cautious.” Vogel says that she has already submitted a grant to test the compound in ferrets, the animals most widely used for influenza studies. “Since eritoran has a very good safety record in people, we would hope that our preclinical studies will ultimately support clinical trials in humans for influenza and possibly other diseases that elicit pathology by a similar mechanism,” she writes in an e-mail to ScienceNOW. To Osterholm, the paper adds to the evidence that influenza causes illness by several different mechanisms. Some influenza strains, like the one that caused the Spanish flu in 1918, or the swine flu in 2009, are more likely to cause death by activating the immune system, leading to more deaths in younger age groups, he argues. “This is where this will have an application.” But Osterholm also cautions that many promising drug candidates fail at later stages. “We won’t know if this works until we put it in people.”last_img read more

0
Read More

Misbah-ul-Haq goes past Sourav Ganguly and MS Dhoni with 10th Test series win

first_imgMisbah-ul-Haq on Tuesday registered his 10th series win as captain as Pakistan hammered West Indies by 133 runs in the second Test to take an unassailable 2-0 lead in the three-match series.Pakistan, riding on the back of a six-wicket haul from Yasir Shah in the second innings, bowled out the visitors for 322 on the final day of the match. Yasir, who had taken two wickets in West Indies’ overnight 171 for four, bowled almost unchanged from the start of the final day to claim four more victims in figures of six for 124, his eighth five-wicket haul and second 10-wicket haul in 18 Tests.Misbah with 10 series victories has now become the most successful Asian captain in Test history, surpassing the record of nine series wins set by former India captains Sourav Ganguly and Mahendra Singh Dhoni. Pakistan legend Javed Miandad was next on the list with eight series wins as captain. (Also read: Yasir Shah becomes joint second fastest to 100 wickets)The win also enabled the hosts to stretch their unbeaten record at the Sheikh Zyed stadium. Out of nine Test played in Abu Dhabi, Pakistan have won five and drawn the rest of the games, which is their best performance on any other stadium in the world. They have a 6-2 record in Dubai and 4-3 in Sharjah.Misbah is also the second-most successful Asian skipper in Test cricket. Ganguly is third on the list with 21 wins as captain of India, Misbah has 24 victories. Dhoni leads the list with 27 Test wins.advertisementMost Test wins as Captain (Asian captains only): Captain Matches Won Lost Draw Win Percentage MS Dhoni (Ind) 60 27 18 15 45.00 Misbah-ul-Haq (Pak) 48 24 13 11 50.00 Sourav Ganguly (Ind) 49 21 13 15 42.85 Sanath Jayasuriya (SL) 38 18 12  8 47.36 Mahela Jayawardene (SL) 38 18 12  8 47.36Most successful Captains for Pakistan: Captain Matches Won Lost Draw Win Percentage Misbah-ul-Haq 48 24 13 11 50.00 Javed Miandad 35 14  5 14 41.17 Imran Khan 48 14  8 26 29.16 Wasim Akram 25 12  8  5 48.00last_img read more

0
Read More

Usain Bolt set to race in Australia for the first time

first_imgUsain Bolt is set to race in Australia for the first time in his career after it was confirmed the nine-times Olympic Gold medallist will take part in the inaugural edition of the Nitro Summer Series in February.The 30-year-old is likely to earn upwards of $1 million for his appearance, according to local media reports.Bolt has already said he plans to retire from the sport after the August 5-13 world championships in London. (Also read: Usain Bolt pictured celebrating 30th birthday with 20-year-old girl in bed)The Jamaican won three Gold medals during this year’s Rio Games to equal distance-runner Paavo Nurmi and American sprinter and long jumper Carl Lewis as the most successful Olympic track and field athletes.Bolt’s fierce American rival Justin Gatlin, who has served two doping bans, has also been linked with the Nitro Series.last_img read more

0
Read More

Nine Awarded for Outstanding Contribution to St. James

first_img Nine persons have been recognized for their outstanding contributions to the development of St. James Jamaicans urged to draw on our history of triumph over adversity Nine persons have been recognized for their outstanding contributions to the development of St. James with the ‘Spirit of Independence’ award during the parish’s Independence Civic Ceremony on August 6.They are Madge Neil Burnett; Roy Graham; Clarice Grant; Beulah Graham; Janet Silvera; Leanora Morris; Matebel Edwards; Sylvia Brown; and Oliver Townsend.“Today we honour our ‘Heroes and Heroines’ at the parish level, for they illustrate true actions and the change we need to see as a nation, in each and every Jamaican.  The recipients of the Spirit of Independence Awards, presented on the occasion of Jamaica’s 51st anniversary of Independence, have all recorded extraordinary achievements at their various spheres of endeavours.  These give testament to the fact that there is joy in hard work and there is no happiness, except in the realization that we have accomplished something,” said Chairman of the Civic and Community Affairs Committee, Councillor Suzette Brown.Mayor of Montego Bay and Chairman of the St. James Parish Council, His Worship Glendon Harris, who presented the awards during the St. James Independence Civic Ceremony at Sam Sharpe Square in Montego Bay, noted that in order for citizens to quantify their love and esteem for the nation, some practical examples such as civic pride and participation in national development must be demonstrated.“The respect and love of which I speak, are founded on the philosophy of loyalty and devotion to a cause, group, individual or nation,” he said.The Mayor said the nation needed to stop, “turn away from the road we are travelling” and “march in a new direction of love and of concern for others … realizing that we have no right to proceed on the present path we are on.”He pointed out that the celebration of the country’s independence brings to mind the exploits of National Hero the Rt. Excellent Samuel Sharpe, who through serious action displayed his love for his people.“During this moment of remembrance, we must aspire towards attaining objectives that will strengthen our nation so we too can compete worldwide, successfully propelling Jamaica to higher heights,” Mayor Harris remarked.Independence Day messages by the nation’s leaders were read at the civic ceremony. The Prime Minister’s message, read by Minister of Labour and Social Security, Hon. Derrick Kellier, urged Jamaicans everywhere at home and abroad, to draw on our history of triumph over adversity.“Our mission must take us briskly along the path of economic growth and national development. Let us reconstruct our society so that all Jamaicans can meaningfully participate in the economic life of the nation.  Let us ensure that every Jamaican is accorded respect and feels a sense of belonging to our society. Let us give full expression to the words of our Motto, ‘out of many, one people’ as we celebrate the blending of our races and cultures and their contribution to nation building,” Prime Minister the Most Hon. Portia Simpson Miller said.Custos the Hon. Ewen Corrodus, read the Governor General’s message in which he urged citizens, not to be discouraged in the face of challenges, but to embrace them as a call to action, serving their country to the best of their abilities.Leader of the Opposition, Anrew Holness, made a call for Jamaicans to renew their commitment to improving the productivity and efficiency of the country’s economy by ensuring that all areas of the labour force is trained and certified and that businesses retool, while incorporating the latest technology into production.Hundreds of persons representing the business, civic and religious communities across the parish attended the ceremony which saw uniformed groups, marching bands and cultural groups bedecked in the Jamaican colors performing in song, dance and drama, adding extra glitter and significance to the historic event. Story Highlights Hundreds representing the business, civic and religious communities across the parish attended the ceremonylast_img read more

0
Read More

Kaushal confesses to killing Congress leader

first_imgGurugram: Dreaded gangster Kaushal, who was recently brought back to India from Dubai and arrested, has confessed of his hand in ordering the killing of Congress leader Vikas Chaudhury.According to police sources, Kaushal had demanded Rs 1 crore from Chaudhary but was rebuffed by the politician, who reportedly told the gangster, “Kal ka ladka mujhse rangdari mangega? Dobara phone mat Karna. (How did a rookie like you dare to make an extortion call to me?) Also Read – After eight years, businessman arrested for kidnap & murderKaushal told his interrogators this hurt his ego. “I asked him (Chaudhary) to pay me protection money of Rs 1 crore. He took me lightly. When I persisted with my demands, he abused me and argued with me,” a senior police officer said, quoting Kaushal. Kaushal thought if he made an example of Chaudhary, his stocks in the underworld would soar further, as would his extortion rates. He needed money to sustain himself in Dubai and eventually take refuge in Zambia. Chaudhary was shot in his car on June 28 after days of extensive recce by Kaushal’s gang members. Kaushal’s hand behind the murder was widely reported in the media; the message Kaushal desired did go out but efforts to bring him back redoubled as well. Also Read – Two brothers held for snatchingsPolice said over the last eight months, Kaushal had extorted money from jewellers, liquor traders and eatery owners in Gurugram,, Faridabad and Palwal and was expanding his network towards Rohtak. He targeted those he knew were tax evaders, so many of his victims chose to quietly pay up. “People who have illegal money cannot come forward with a complaint as it will be difficult for them to explain their source of money,” said a police officer. The terror of Kaushal gang can be gauged from the fact that in just this year itself there have been four murders that have occurred in Gurugram. Just as in the case of Vikas Chaudhary the victims were gunned down in the busy streets.last_img read more

0
Read More

“I haven’t met a more passionate actor than Mr. Bachchan”, says Anand Pandit

first_imgMumbai, Date: In industry circles veteran producer Anand Pandit’s close friendship with legend Amitabh Bachchan is no secret. Given the long association it was no surprise when Anand Pandit recently announced the next film under his banner Anand Pandit Motion Pictures with Big B and Emraan Hashmi. To be directed by Rumi Jaffrey,Chehre has now gone on floors. The film also features Annu Kapoor in a pivotal role.The shoot began in the city and mostly will be shot in the mountains as well, the film will see Anand Pandit taking lead as a producer as well as work closely on the creative aspects of the project. Also Read – ‘Terminator: Dark Fate’ has James Cameron’s fingerprints all over it: Arnold SchwarzeneggerProducer Anand Pandit is elated to be working with the superstar and said, “The shoot has started and we are all set to finish the schedules on time. I haven’t met a more passionate actor than Mr. Bachchan. Every shot, every scene is a joy to shoot with him and the entire crew is having a great experience.”Anand Pandit is a producer with a prolific list of films. Having associated with films like ‘PM Narendra Modi’, ‘Total Dhamaal, ‘Baazaar’. The filmmaker has also been associated with ‘Pyaar Ka Punchnama 2’, ‘Satyameva Jayate’, ‘Batti Gul Meter Chalu’, ‘Sarkar 3’ and ‘Missing’.last_img read more

0
Read More

Chomsky: U.S. Bears Greatest Responsibility For Israeli Aggression Against Gaza

Tinjedad, Morocco- Noam Chomsky, the Jewish American linguist who has gained a reputation as one of Israel’s fiercest critics, has accorded the United States the greatest responsibility in the latest Israeli aggression on Gaza, according to Anadolu Agency.Chomsky asserted that the U.S. contributes directly to the massacres committed against the Palestinians, through the military, political, diplomatic, and ideological support which it provides for Israel, referring to Israel’s use of the latest, most destructive U.S. arms against the Palestinian people.Speaking to the Turkish news agency, Chomsky said that the suffering of the Palestinians has proved that there is no such thing as an “international community” since citizens in all parts of the world have waited in vain for the “international community” to do something. The leading American philosopher and political activist added that, “The concept of the international community, is but an empty and meaningless term, a trick and illusion to ordinary people.”Chomsky said that Turkey is the only country which has voiced strong opposition to Israel, and [made it clear through denouncing the injustices levied on the PalestiniansThe same source quoted the American activist as saying “While the European Union does not care about what is happening today in Gaza, the Arab world is suffering from deep division which deprives it of the power to do anything.”According to the World Jewish Congress, Chomsky “accused Israel of committing crimes that were ‘far worse’ than those perpetrated by the white nationalist regime in South Africa.”With respect to the Palestinian cause, Chomsky said he does not expect any resolution from the United Nations because “the UN organization is not a strong and independent actor in the world of politics, but only a body that carries out the wishes of the most powerful countries in the world.”© Morocco World News. All Rights Reserved. This material may not be published, rewritten or redistributed read more

0
Read More

Blackmail: French Journalists Lose Book Deal About Moroccan King

Rabat – French publishing house ‘Editions Le Seuil’ has announced Monday it would cancel a book publishing deal with journalists Eric Laurent and Catherine Graciet after they were accused of attempting to blackmail King Mohammed VI of Morocco last week. The freelance investigative journalists are accused of demanding € 3 million from the Moroccan monarch in order to abstain from publishing a book that allegedly contains ‘damaging revelations’ about the royal family and its financial affairs.“Under these conditions, the publication [due for January 2016] will not go ahead,” Editions Le Seuil, owned by La Martinière Groupe, said in a statement. The pair was arrested last Thursday as they left a restaurant in the French capital where they had a meeting with a representative of the Moroccan palace.They admitted to having received € 80,000 (€ 40,000 each) as down-payment on the €3 million they wanted to extort from the Moroccan monarch.Laurent told French newspaper Le Monde he accepted the money because his wife was “severely ill”, while Graciet told Le Parisien she “had a moment of weakness”.© Morocco World News. All Rights Reserved. This material may not be published, rewritten or redistributed without permission read more

0
Read More

UN climate change chief urges nations to step up search for common

4 October 2010With less than two months remaining before the next United Nations Climate Change Conference in Cancún, a senior world body official called on nations to accelerate efforts to find common ground to reach a concrete outcome at the Mexico meeting. “Governments have restored their own trust in the process, but they must ensure that the rest of the world believes in a future of ever-increasing government commitment to combat climate change,” said Christiana Figueres, Executive Secretary of the UN Framework Convention on Climate Change (UNFCCC).Some 3,000 participants from more than 170 countries are in Tianjin, China, for a negotiating session which began today ahead of the next conference of parties in Cancún kicking off on 29 November.“Governments need to agree on what is doable in Cancún and how it will be achievable in a politically-balanced manner,” Ms. Figueres stressed.She noted there is a growing convergence in the negotiations that the event in the Mexican city could lead to a package of decisions defining action to address climate change.This could include a new global framework to help countries adapt to climatic changes, launching a new mechanism to speed up the transfer of technology to developing nations, and setting up a new fund to oversee money raised for specific needs of poorer countries related to climate change.“The agreements that can be reached in Cancún may not be exhaustive in their details, but as a balanced package, they must be comprehensive in their scope and they can deliver strong results in the short-term as well as set the stage for long-term commitments to address climate change in an effective and fair manner,” the UNFCCC chief said.She acknowledged that there are areas where nations disagree, mainly over how and when to agree on a fair share of responsibilities on present and future action, but underlined that they are not insurmountable.“Governments seem ready to discuss difficult issues,” Ms. Figueres said. “Now they must bridge differences in order to reach a tangible outcome in Cancún.”For example, she said, they can formalize the many pledges they have made to cut and limit emissions.The recent floods in Pakistan, fires in Russia and mudslides in China have spotlighted the dangers of extreme climate events, the official pointed out.“The bottom line is that it is in no one’s interest to delay action,” she said. “Quite on the contrary, it is in everyone’s ultimate interest to accelerate action in order to minimize negative impacts on all.” read more

0
Read More

Côte dIvoire senior UN official urges justice for victims of human rights

The call by High Commissioner for Human Rights Zeid Ra’ad Al Hussein comes in the wake of the guilty verdicts against numerous supporters of former President Laurent Gbagbo charged with offences against the state and its institutions.“Victims of gross human rights violations, some of which may constitute war crimes and crimes against humanity, have yet to see justice almost four years since the end of the conflict in Côte d’Ivoire,” he stated in a news release. “Perpetrators of killings, rapes and other serious breaches of international law – no matter what their background or affiliations – must be promptly prosecuted.” Côte d’Ivoire’s 2010 presidential election, meant to be the culminating point in a long-running UN-backed peace process, resulted in months of violence – that led to several thousand deaths and numerous human rights violations – when Mr. Gbagbo refused to step down after losing to Alassane Ouattara. Mr. Gbagbo finally surrendered in April 2011. According to media reports, the country’s former first lady, Simone Gbagbo, was sentenced this week to 20 years in jail for her role in the post-electoral violence. Her husband, meanwhile, is awaiting trial at the International Criminal Court. “It is unacceptable that not a single individual has so far been convicted in a civilian court in Côte d’Ivoire on conflict-related human rights violations. And it is deplorable that some of the alleged perpetrators continue to hold official positions of responsibility,” said the High Commissioner. “While I understand that the case which has just ended was of great significance to the Government, I urge it to now turn its attention to these extremely important human rights cases, without further delay.” The human rights chief also pointed out that this week’s verdict in the case against 83 alleged supporters and relatives of Mr. Gbagbo laid bare structural deficiencies in the judicial system in Côte d’Ivoire that need to be urgently addressed. “For the peace gains to be secured and sustainable,” he added, “Côte d’Ivoire must prioritize equitable justice, truth and reconciliation, particularly ahead of the presidential elections later this year.” read more

0
Read More

Ohio State footballs Kerry Coombs Chris Ash and I are going to

OSU cornerbacks coach and special teams coordinator Kerry Coombs talks to the media on National Signing Day Feb. 5 at the Woody Hayes Athletic Center.Credit: Shelby Lum / Photo editorWith the introduction of Ohio State’s new co-defensive coordinator and safeties coach Chris Ash, some questions had to be answered.What is he going to do to fix a pass defense that finished 2013 ranked 112th in the country? How does he feel about the group of young players that will be playing next season?But perhaps the most important quandary is how cornerbacks coach and special teams coordinator Kerry Coombs and Ash will get along.“What I would tell you is that Chris and I are going to function as a team in the back end. We will have one voice,” Coombs told the media on National Signing Day Wednesday. “We both may be saying it, but we’ll be saying the same thing so that when we meet together, when we coach together, when we’re practicing together, we’re all using the same terms, the same phrases, the same words, coaching things and I don’t know, the same style. I haven’t been able to watch Chris coach, I don’t know his style yet, but (we’ll be) using all of the same language and verbiage out there. And I think that’s very important.”Coombs, who has been with the program for each of the last two seasons, added that there is not a rigid set of rules dictating who coaches what on any given day.“I believe very strongly that those things, the more you can do things in a group setting, the better off you’re going to be,” Coombs said. “And so our approach — Chris and I will work together to make that happen and there will be times when we will be working right half and left half. And at times, we’ll be working corners and safeties and at times we’ll be functioning with four guys doing things together … I would think they would tell you the same thing, that all of that will lead, I think, to great communication, which should be our objective moving forward.”Ash spent 2013 at Arkansas after spending three seasons with one of OSU’s Big Ten rivals, Wisconsin.Agreeing with his new coaching partner Coombs, Ash said coaching on the defensive side of the ball will be all about balancing everyone.“Everything we’re going to do is going to be a team effort,” Ash said. “You know a lot of people have asked about coach Coombs and I coaching the secondary. It’s going to be a team effort, and the defensive staff is a team, putting this package together. Trying to identify the direction we’re going to go and what we need to get fixed, and gameday, it’ll be a team effort.”At Wisconsin, Ash was a part of three consecutive Big Ten Championships and led a pass defense that finished an average of 16th in the country during his tenure.A big part of improving the Buckeyes’ struggles against the pass is changing the mentality, Ash said.“Well you play fast, you play with reckless abandon, you’re fast, you’re physical, you throw your body around,” Ash said. “There’s no confusion, you know exactly what you’re doing. You can react to your key and there’s only one speed: it’s full speed. And that’s the way we gotta play.”Coombs agreed, saying the intensity of play is likely to increase in 2014.“Yeah, I would think you would see a more aggressive style of play across the board from alignment to attack and so forth,” Coombs said.The secondary is only returning one regular starter in junior cornerback Doran Grant, and Coombs said it’s impossible to predict who is going to win the starting positions because players are battling for them.“There will be some changes. The competition I would tell you is wide open,” Coombs said. “You’ve got to perform to play. And I think that the expectation on the part of every player on this football team is you gotta show up every day and you’ve got to perform in order to play in the fall. We’re going to work really hard on finding those guys who can compete and who will challenge in tough situations.”Coach Urban Meyer said Wednesday the defense needed something new after struggling in the latter part of the season.“We won a lot of games, but there were some holes,” Meyer said. “Holes very easy to blame players or blames coaches. Just overall, we need to freshen up our defense. That’s what’s going to take place over the next few months.”Ash and Coombs are set to receive their first chance to patrol the Buckeye sidelines together Aug. 30 when OSU is scheduled to take on Navy at M&T Bank Stadium in Baltimore. read more

0
Read More

Northern Stars South Kalgoorlie gold mine enters the Monitor Pro fold

first_imgAustralia’s Northern Star Resources has chosen to run EHS Data’s Monitor Pro environmental management system at its South Kalgoorlie gold mine in Western Australia, as the miner looks to bring its newly-acquired operation inline with its other five assets.Use of the MCERTS-accredited software at South Kalgoorlie has allowed the environmental team at Northern Star to streamline its reporting structure by replacing the old spreadsheet system into a “single, centralised source of data for the entire environmental operations”, EHS said.MonitorPro provides a single, centralised source of data and reporting for the entire environmental and sustainability operation. “Through an easy to use dashboard you can manage data and produce accurate reporting and analytics – quickly and painlessly,” EM Data said.The programme also integrates with MS Office to fit with existing workflows, making managing environmental data easier.Northern Star acquired South Kalgoorlie back in April from Westgold Resources in an A$80 million deal. It included the operating processing facility and 800 km² of prospective gold tenure.MonitorPro has been operational in Northern Star’s gold mines for several years.last_img read more

0
Read More

Vote for the Worlds Best Female Player 2011

← Previous Story WCh 2011 “All Stars Team” – Seven players from seven NT, no MVP Next Story → EURO 2012 without two big stars – Szmal and Sterbik injured After more than 6500 Handball fans worldwide decided that Laszlo Nagy is the Best World’s Handball Player in 2011, Handball-Planet.com organising the First Voting Contest for the World’s Best Female Handball Player in 2011. Our Jury consisted of journalists and successful coaches with International background made a list of seven players as for the Men’s competition. They were the best on their positions in our opinion in the EHF Champions League, domestic Leagues or with their National Teams at the World Championship in Brasil.The “BEST SEVEN” are:Silvia Navarro Gimenez (Goalkeeper, Itxako Navarra and Spain)Emiliya Turey (Left wing, Rostov Don – Itxako and Russia)Andrea Penezic (Left back, Krim Mercator and Croatia)Allison Pineau (playmaker, Metz and France)Linn Jolum Sulland (right back, Larvik and Norway)Carmen Martin Berenguer  (right wing, Itxako Navarra and Spain)Heidi Loke (line player,Gyori and Norway)VOTE read more

0
Read More

Micron creates smallest ever 128Gb flash memory chip using 16nm process

first_imgMicron has announced that it is now manufacturing samples of its latest 128Gb flash memory chips using a 16nm process. In so doing, it has created the smallest ever 128Gb (16GB) multi-level cell (MLC) NAND Flash memory.By making the chips smaller, Micron says it can create 6TB of storage on a single wafer. That means the cost per chip will be lower and the size saving will allow for more storage to be packed into devices such as USB sticks and SSDs.The last time we saw a shift to a smaller process was last year when SanDisk moved to a 19nm process and Intel started shipping SSDs using 20nm chips. 16nm sets the bar higher, or lower depending on how you look at it, for other manufacturers to try and match. By getting there first, Micron holds the advantage as it can offer flash memory cheaper while retaining its profit margin.For consumers it should eventually lead to cheaper SSDs and USB sticks, as well as allowing more memory to be included in products. Hopefully this means terabyte-size SSDs with an affordable price tag get a step closer, too. Micron also has its eye on ultra-thin laptops, mobile devices, and even data centers for cloud storage.Full production of these new 16nm chips is expected to start in the 4th quarter of this year. Micron is planning to roll out a line of new SSDs that use the chips in early 2014.last_img read more

0
Read More

Greek MPs vote in austerity measures amid protests

first_imgGreek MPs have voted in favour of a joint European Union/IMF bailout deal this morning, as violent protests raged in the streets of Athens, and spread to Corfu, Crete and Thessaloniki.The new austerity measures will see Greece receive a €130billion bailout and secure a deal with private creditors to remove €100billion from the national debt. In a bid to avoid national bankruptcy, the bill authorises cuts in wages, pensions and jobs amounting to almost $4.5 billion this year alone.The vote, which took place in a sepcial late night meeting, came amidts a renewed violence on the streets of Athens, as around 80,000 protesters clashed with riot police in Ominia Square angered by the potential of new austerity measures. 54 people were injured. “Vandalism, violence and destruction have no place in a democratic country and won’t be tolerated,” Mr Papademos told parliament as they prepared to make the historic vote. “It would be a huge historical injustice if the country from which European culture sprang … reached bankruptcy and was led, due to one more mistake, to national isolation and national despair.” Facebook Twitter: @NeosKosmos Instagramlast_img read more

0
Read More

Woodland bus ride disrupted after gun bomb discussion

first_imgA school bus ride in Woodland was briefly interrupted Tuesday afternoon when the bus driver overheard students discussing guns and bombs.Woodland Public Schools Superintendent Michael Green wrote a note about it to parents that was posted to the district’s website and social media accounts Tuesday night. A note also was sent home with students on Wednesday.The driver overheard the conversation between two high school students on their way home from school Tuesday and was concerned for student safety, the note says.Following protocol, the driver parked the bus and evacuated the students on board. Woodland police officers then responded and inspected the bus, eventually determining that there was no actual threat and that the two students had been joking, Green wrote. Investigators determined no crime was involved and are letting the school district determine disciplinary action, Woodland police officer Jim Keller said.No decision has been made about what discipline the students will face, school district spokesman Eric Jacobson said.Green encouraged parents to speak with their children about inappropriate conversations both at school and on school transportation. He also emphasized the importance of sharing with adults information about potentially dangerous situations.last_img read more

0
Read More

Russian billionaire could invest in Everton

first_imgAlisher Usmanov sold his shares for 30% of Arsenal but wants to invest in a new football club, especially in the Premier LeagueAccording to The Daily Post, Russian billionaire Alisher Usmanov could consider investing in Premier League Everton.The businessman sold his 30% stake at Arsenal a few days ago to American Stan Kroenke but doesn’t want to leave the football business.Harry Maguire, Manchester UnitedSolskjaer praises Harry Maguire after Man United’s 1-0 win Andrew Smyth – September 14, 2019 Ole Gunnar Solskjaer singled out Harry Maguire for praise after helping Manchester United keep a clean sheet in their 1-0 win over Leicester City.The entrepreneur told Bloomberg today how he’s a close friend of Farhad Moshiri, The Blues’ major shareholder, and how he could invest on the team.“If he needs the support, I am happy to help.”“Should there be a proposal or a possibility to invest in them with good potential returns, I would consider the deal,” he added.last_img read more

0
Read More

Rap Yearbook To Join AMC Visionaries Lineup As New Miniseries

first_imgNews Content Not Available Twitter ‘Rap Yearbook’ Miniseries Headed To AMC rap-yearbook-join-amc-visionaries-lineup-new-miniseries Facebook  Cast Your Vote: What Was The Most Influential Rap Track Of The 2000s?center_img The bestselling year-by-year breakdown of the greatest songs in rap history will soon be a new docu-miniseries on AMC, executive produced by the Roots’ Questlove and Black ThoughtBrian HaackGRAMMYs Aug 1, 2017 – 9:32 am GRAMMY.comAMC’s new forays into deep-dive documentary style programming will soon bear musical fruit, with the newly announced six-part miniseries The Rap Yearbook — based on Shea Serrano’s critically acclaimed bestselling book of the same name — set to premiere on the network in 2018.Serrano’s year-by-year breakdown of the progression of the rap game, from its earliest iterations in 1979 to its place atop the throne of popular music in 2015, spotlights key songs from each year and assesses their significance — analyzing what each track has to say about the genre, the artists and the cultural moment of its place in music history.The televised version of Serrano’s work will be included as part of AMC’s new “Visionaries” initiative, which will feature a variety of new limited-run series that AMC President Charlie Collier has characterized as, “all about going deep into areas of fan passion,” in a recent interview with Variety. Hosts and contributors to the discussion will include legacy artists, music experts and other giants of the scene. Multi-GRAMMY winners Ahmir “Questlove” Thompson and Tariq “Black Thought” Trotter of the Roots have been tapped as the executive producers charged with helping shape the new show’s overarching vision.Similar to the format of the show’s source material, each episode will center on debate and introspection about key moments in the development of hip-hop, framed around a particular song that is clearly emblematic of an important shift in the genre.The announcement of the new show signals the endgame of a long development process for the televised iteration of Serrano’s The Rap Yearbook; it was initially teased by Fader as far back as March 2016 that an expanded documentary version could be forthcoming.Serrano is, of course, justifiably stoked about the new project. https://twitter.com/SheaSerrano/status/711995623348645889 Email ‘Rap Yearbook’ To Join AMC Visionaries Lineup As New Miniseries last_img read more

0
Read More

Felony count climbs to 13 in sexual assault case against Sitka doctor

first_imgTwo more felony sexual assault charges have been brought against a Sitka physician, bringing the total now to 13. A Sitka grand jury on Thursday indicted 75-year-old Richard McGrath on two counts of sexual assault in the second degree, for allegedly touching the breast of a female patient while she was unaware that a sexual act was being committed. McGrath has pleaded not guilty to all previous charges. He is being represented by Juneau defense attorney Julie Willoughby, who has told the court that her client intends to go to trial to clear his name. McGrath was placed on administrative leave by Sitka Community Hospital in December, where he had worked under contract for four years. He was scheduled to begin work under a new contract when the original charges came to light. McGrath has been scheduled for trial in December of this year. At the time of his arraignment in Sitka Superior Court on May 23, it wasn’t clear whether the separate cases against McGrath would be consolidated into a single trial. That question will likely come up again when McGrath is arraigned on these most recent charges on June 7. McGrath has been indicted twice previously this spring on 11 counts of alleged sexual assault against two separate victims going back to November of last year. The new charges involve a third victim, who was allegedly assaulted in March of 2018. McGrath remains free on $25,000 bail, and has returned to his Seattle-area home.last_img read more

0
Read More

Telangana BJP president slams KCR for not making dalit as chief

first_imgTelangana BJP president K Laxman took a dig at chief minister K Chandrasekhar Rao for not making a Dalit as chief minister. Referring to the government’s initiative of providing three-acre land to the Dalits, Laxman said that the government insulted the Dalits by giving barren lands. Speaking to the media at Ambedkar Bhavan near lower tank bund, he alleged that the government is misleading the sub-plan funds. The BJP leader also questioned the government as to why it has not constructed the Ambedkar Bhavan even three years after its assurance. Later, he planted saplings at the Ambedkar Bhavan.last_img read more

0
Read More